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KMID : 0043320110340050723
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Archives of Pharmacal Research
2011 Volume.34 No. 5 p.723 ~ p.726
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A new cytotoxic coumarin, 7-[(E)-3′,7′-dimethyl-6′-oxo-2′,7′-octadienyl] oxy Coumarin, from the leaves of Zanthoxylum schinifolium
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Min Bo-Kyung
Hyun Dong-Geol
Jeong Su-Yang
Kim Young-Ho
Ma Eun-Sook
Woo Mi-Hee
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Abstract
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A new coumarin, 7-[(E)-3′,7′-Dimethyl-6′-oxo-2′,7′-octadienyl]oxy coumarin (1), together with three known compounds, schinilenol (2), schinindiol (3) and 7-[(E)-7′-hydroxy-3′,7′-dimethylocta-2′,5′-dienyloxy]-coumarin (4) were isolated from the methylene chloride fraction of Z. schinifolium by normal and reverse phase column chromatographies. Their structures were determined on the basis of physical and spectroscopic evidences. Compound 1 (IC50 8.10 μM) showed potent cytotoxicity compared to auraptene (IC50 55.36 μM) against Jurkat T cells. The other isolated compounds 2 and 4 exhibited weak cytotoxicities.
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KEYWORD
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Zanthoxylum schinifolium, Rutaceae, 7-[(E)-3′, 7′-Dimethyl-6′-oxo-2′, 7′-octadienyl] oxy coumarin, Cytotoxicity
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